منابع مشابه
Genetics of affective disorders.
Despite substantial evidence for heritability in affective disorders the contributing genes have proven elusive. Here we discuss the genetic epidemiology of depression, as well as methodological issues and results from molecular genetic studies. There has been rapid advances in genetics, genomics and statistical modelling, facilitating the search for molecular mechanisms underlying affective di...
متن کاملEvolutionary genetics of affective disorders
I review evolutionary-genetic models for the generation, maintenance and loss of allelic variation underlying polygenic disease, in the context of affective disorders and related conditions. Genetically-based liability to these disorders appears to be due to some combination of mutation-selection balance involving common, small-effect variants and rare, large-effect variants, and natural select...
متن کاملBehavioral genetics of affective and anxiety disorders.
As shown by clinical genetic studies, affective and anxiety disorders are complex genetic disorders with genetic and environmental factors interactively determining their respective pathomechanism. Advances in molecular genetic techniques including linkage studies, association studies, and genome-wide association studies allow for the detailed dissection of the genetic influence on the developm...
متن کاملAffective instability, family history of mood disorders, and neurodevelopmental disturbance.
The association between affective instability and both family history of mood disorders and signs of neurodevelopmental disturbance was examined in a sample of 303 adults. Affective instability was measured using the borderline personality disorder "affective instability due to a marked reactivity of mood" diagnostic criterion as assessed dimensionally using the Personality Disorder Interview--...
متن کاملTheoretical and clinical overview of affective temperaments in mood disorders
Temperaments are imperturbable variations of personality, traits and ways of reacting to the environment that characterize individuals and remain constant throughout several different situations. Temperaments usually play a central role in determining emotional reactions, therefore several temperamental models have attempted to establish the potential relationship between temperaments and affec...
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ژورنال
عنوان ژورنال: European Journal of Human Genetics
سال: 2006
ISSN: 1018-4813,1476-5438
DOI: 10.1038/sj.ejhg.5201549